This is an excellent summary of the side effects of Prozac for women. One paragraph stood out for me though, since I take zoloft: "You might consider switching to Zoloft. It has a lower side effect profile, overall. Although it does still have the problems with decreased libido, it is possible to get around this with Zoloft. Because it stays in the body a shorter amount of time it is possible to take a "drug holiday." If you discontinue the drug for a weekend (2-4 days), your normal sex drive and response will return, quickly. The drug can be resumed after short periods without a loss of clinical effectiveness." What happens in a "Drug Holiday" is that you get depressed again, and it shows, and people notice, and especially at work you pay the price. So if you're the breadwinner, take the pills. There are things you have to give up to function when you have depression. If sex is one of them, you have to deal with it.